MUTAGENIC ACTION OF MITOMYCIN C ON DROSOPHILA MELANOGASTER
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چکیده
منابع مشابه
Mutagenic Action of Mitomycin
HE antibiotic mitomycin C (MC) is mutagenic in some strains of Escherichia Tcoli in which it also increases the frequency of recombination (IIJIMA and HAGIWARA 1960). Studies on the effects of MC in Ustilago and Saccharomyces indicate that it is nonmutagenic in these organisms although it does increase mitotic crossing over (HOLLIDAY 1964). SUZUKI (1965) has found that MC increases crossing ove...
متن کاملEffects of Mitomycin C on Crossing over in Drosophila Melanogaster.
RECENT evidence indicates that a large proportion of increases in crossing over induced in Drosophila melanogmter females is of gonia1 ongin (WHITTINGHILL 1955; THOMPSON 1964; SUZUKI 1965). HOLLIDAY (1964) and ESPOSITO and HOLLIDAY (1964) find that treatment of Ustilago and Saccharomyces with agents that inhibit DNA replication (mitomycin C, 5-fluorodeoxyuridine) results in increased somatic re...
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Translocations between the two large autosomes were scored in the progeny of males that had been fed mitomycin-C. The frequencies were the same in spermatogonia sampled after 12 and 25 days and in spermatozoa stored for the same periods in untreated females.
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Rapoport (1946), Kaplan (1948), and Auerbach (1949) found formaldehyde highly mutagenic for Drosophila when administered with its food. Auerbach (1949), however, observed negative results when Drosophila was exposed to formaldehyde vapor and concluded that formaldehyde acts indirectly through chemical changes brought about in food constituents. Dickey, Cleland, and Lotz (1949) found formaldehyd...
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ژورنال
عنوان ژورنال: Genetics
سال: 1965
ISSN: 1943-2631
DOI: 10.1093/genetics/51.6.947